It is expected that the safety of keppra xr in elderly patients 65 and over would be comparable to the safety observed in clinical studies of immediate-release keppra tablets.
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In vitro and in vivo recordings of epileptiform activity from the hippocampus have shown that levetiracetam inhibits burst firing without affecting normal neuronal excitabilitysuggesting that levetiracetam may selectively prevent hypersynchronization of epileptiform burst firing and propagation of seizure activity.
KEPPRA is contraindicated in patients with a hypersensitivity to levetiracetamReactions have included anaphylaxis and angioedemasee WARNINGS AND PRECAUTIONS
The overall adverse reaction profile of KEPPRA was similar between females and malesThere are insufficient data to support a statement regarding the distribution of adverse reactions by age and race.
Because clinical trials are conducted under widely varying conditionsadverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in practice.
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