Mefloquine major concurrent use of citalopram and mefloquine should be avoided due to an increased risk for qt prolongation and torsade de pointes tdp .
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Although in controlled studies Celexa has not been shown to impair psychomotor performanceany psychoactive drug may impair judgmentthinkingor motor skillsso patients should be cautioned about operating hazardous machineryincluding automobilesuntil they are reasonably certain that Celexa therapy does not affect their ability to engage in such activities.
Because citalopram is extensively metabolizedexcretion of unchanged drug in urine is a minor route of eliminationUntil adequate numbers of patients with severe renal impairment have been evaluated during chronic treatment with Celexahoweverit should be used with caution in such patientssee DOSAGE AND ADMINISTRATION
Metabolic and Nutritional DisordersFrequentdecreased weightincreased weightInfrequentincreased hepatic enzymesthirstdry eyesincreased alkaline phosphataseabnormal glucose toleranceRarebilirubinemiahypokalemiaobesityhypoglycemiahepatitisdehydration.
Adverse events during exposure were obtained primarily by general inquiry and recorded by clinical investigators using terminology of their own choosingConsequentlyit is not possible to provide a meaningful estimate of the proportion of individuals experiencing adverse events without first grouping similar types of events into a smaller number of standardized event categoriesIn the tables and tabulations that followstandard World Health OrganizationWHOterminology has been used to classify reported adverse events.
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undesirable effects may be more common during concomitant use of citalopram and herbal preparations containing st john s wort hypericum perforatum .