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The following adverse reactions were observed and have been reported with use of formulations of sustainedor immediate-release propranolol.
The mechanism of the antihypertensive effect of propranolol has not been establishedAmong factors that contribute to the antihypertensive action are1decreased cardiac output2inhibition of renin release by the kidneysand3diminution of tonic sympathetic nerve outflow from vasomotor centers in the brainAlthough total peripheral resistance may increase initiallyit readjusts to or below the pretreatment level with chronic useEffects of propranolol on plasma volume appear to be minor and somewhat variable.
Some products that may interact with this drug includealpha blockerse.gprazosinaluminum hydroxideanticholinergicse.gatropinescopolaminechlorpromazineother drugs to treat high blood pressuree.gclonidinehydralazinemethyldopaepinephrinefingolimodhaloperidolother heart medicationse.gdigoxindisopyramidepropafenonequinidinemefloquinerizatriptantheophyllinethioridazinethyroid hormonese.glevothyroxinewarfarindrugs affecting liver enzymes that remove propranolol from your bodysuch as cimetidineStJohn’s wortcertain SSRI antidepressants including fluoxetine/paroxetine/fluvoxamineHIV protease inhibitors including ritonavirrifamycins including rifabutin
In patients with coronary artery diseaseabruptly stopping propranolol can suddenly worsen anginaand occasionally precipitate heart attacksIf it is necessary to discontinue propranololits dosage should be reduced gradually over several weeks.
Cardiogenic shock or decompensated heart failure Sinus bradycardiasick sinus syndromeand greater than first-degree block unless a permanent pacemaker is in place Bronchial asthma Known hypersensitivitye.ganaphylactic reactionto propranolol hydrochloride or any of the components of INNOPRAN XL Close.
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