Quinidine, verapamil, amiodarone, propafenone, indomethacin, itraconazole, alprazolam, and spironolactone raise the serum digoxin concentration due to a reduction in clearance and or in volume of distribution of the drug, with the implication that digitalis intoxication may result.

Information about Digoxin.
Rememberkeep this and all other medicines out of the reach of childrennever share your medicines with othersand use this medication only for the indication prescribed.
Avoid rapid IV administration in digitalized patientsmay produce serious arrhythmias.
Results were pooled and took into account the differences between study resultsdue to their different study designheterogeneity
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the mediation can influence the bioavailability of digoxin which will require the dosage adjustments of the later.