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PATIENTS WITH BRONCHOSPASTIC DISEASES SHOULDIN GENERALNOT RECEIVE BETA-BLOCKERSBecause of its relative beta1 cardio-selectivityhoweverTOPROL-XL may be used in patients with bronchospastic disease who do not respond toor cannot tolerateother antihypertensive treatmentBecause beta1selectivity is not absoluteuse the lowest possible dose of TOPROL-XLBronchodilatorsincluding beta2agonistsshould be readily available or administered concomitantlysee DOSAGE AND ADMINISTRATION

Shortness of breathbeing less able to exercise swelling of the anklesfeet or legs chest tightnesswheezingnoisy breathingdifficulty breathing chest painchanges in heart rate or palpitations swelling of the facelipstongue or throat which may cause difficulty in swallowing or breathingwhich may be signs of a serious allergic reaction yellowing of the skin or eyesjaundicegenerally feeling unwell.

Your doctor and pharmacist have more information on medicines to be careful with or avoid while taking TOPROL-XL.

Beta-blockers may mask tachycardia occurring with hypoglycemiabut other manifestations such as dizziness and sweating may not be significantly affected.

If you have diabetesthis product may mask the fast/pounding heartbeat you would usually feel when your blood sugar falls too lowhypoglycemiaOther symptoms of low blood sugarsuch as dizziness and sweatingare unaffected by this drugThis product may also make it harder to control your blood sugarCheck your blood sugar regularly as directed and share the results with your doctorTell your doctor right away if you have symptoms of high blood sugar such as increased thirst/urinationYour doctor may need to adjust your diabetes medicationexercise programor diet.

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the metoprolol could also cause swelling in your hands and feet, which may lead to some weight gain.

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