At toxic doses, colchicine may cause severe diarrhea, generalized vascular damage, and renal damage with hematuria and oliguria.
Information about Colchicine.
Avoid eating grapefruit or drinking grapefruit juice while taking colchicine capsulesIt can increase your chances of getting serious side effects.
Toxic manifestations associated with colchicine include myelosuppressiondisseminated intravascular coagulationand injury to cells in the renalhepaticcirculatoryand central nervous systemThese most often occur with excessive accumulation or overdosagesee OVERDOSE
Physicians should ensure that patients are suitable candidates for treatment with colchicine capsules and remain alert for signs and symptoms of toxic reactions associated with increased colchicine exposure due to drug interactionsSigns and symptoms of colchicine toxicity should be evaluated promptly andif toxicity is suspectedcolchicine capsules should be discontinued immediately.
Patients with renal or hepatic impairment should not be given colchicine capsules with drugs that inhibit both P-glycoprotein and CYP3A4 inhibitorsSee DRUG INTERACTIONSCombining these dual inhibitors with colchicine in patients with renal or hepatic impairment has resulted in life-threatening or fatal colchicine toxicity.
If you are taking colchicine to prevent gout attackscall your doctor right away if you experience a gout attack during your treatmentYour doctor may tell you to take an extra dose of colchicinefollowed by a smaller dose one hour laterIf you take extra doses of colchicine to treat a gout attackyou should not take your next scheduled dose of colchicine until at least 12 hours have passed since you took the extra doses.
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concomitant use of clarithromycin and colchicine is contraindicated in patients with renal or hepatic impairment see warnings .