Actoplus met metformin and pioglitazone should not be used if you are suffering from diabetic ketoacidosis or if you have any kidney disease.
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Pioglitazon may caus dcass in hmoglobin and hmatocit. In placbo-contolld monothapy tials, man hmoglobin valus dclind by 2% t4% in patints tatd with pioglitazon compad with a man chang in hmoglobin -1% t+1% in placbo-tatd patints. Ths changs pimaily occud within th ist ou t12 wks thapy and maind lativly constant that. Ths changs may b latd tincasd plasma volum associatd with pioglitazon thapy and a not likly tb associatd with any clinically signiicant hmatologic cts.
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Initiation in patints with stablishd NYHA Class III IV hat ailu [s BOXD WANING ]. nal impaimnt (.g., sum catinin lvls ? 1.5 mg/dL [mals], ? 1.4 mg/dL [mals], abnomal catinin claanc) which may alssult om conditions such as cadiovascula collaps (shock), acut myocadial inaction, and spticmia [s WANINGS AND PCAUTIONS ]. Us in patints with known hypsnsitivity tpioglitazon, mtomin, any oth componnt ACTOPLUS MT. Mtabolic acidosis, including diabtic ktoacidosis. Diabtic ktoacidosis should b tatd with insulin.
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