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High doses or long-term use of clozapine can cause a serious movement disorder that may not be reversibleSymptoms of this disorder include uncontrollable muscle movements of your lipstongueeyesfacearmsor legsThe longer you take Clozarilthe more likely you are to develop a serious movement disorderThe risk of this side effect is higher in women and older adults.

Severe nervous system reactionvery stiffrigidmuscleshigh feversweatingconfusionfast or uneven heartbeatstremorsfeeling like you might pass out;

In patients in whom the interval since the last dose of Clozaril exceeds 2 daystreatment should be re-initiated with 12.5 mg given once or twice on the first dayIf this dose is well toleratedit may be feasible to titrate the dose to the therapeutic level more quickly than is recommended for initial treatmentHoweverin any patient who has previously experienced respiratory or cardiac arrest with initial dosingsee section 4.4but was then able to be successfully titrated to a therapeutic dosere-titration should be carried out with extreme caution.

It may take several weeks before the full benefit of this drug takes effectInform your doctor if your condition persists or worsens.

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although it has not been established that there is an interaction between clozaril and benzodiazepines or other psychotropics, caution is advised when clozapine is initiated in patients taking a benzodiazepine or any other psychotropic drug.

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