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Before using this medicationtell your doctor or pharmacist your medical historyespecially ofkidney diseaseliver diseaseconditions that may cause a low level of oxygen in the blood or poor circulationsuch as severe congestive heart failurerecent heart attackrecent strokeserious infectionsevere loss of body fluidsdehydrationalcohol usesevere breathing problemssuch as obstructive lung diseasesevere asthmablood problemssuch as anemiavitamin B12 deficiencyelectrolyte imbalancehyponatremiafertility problemssuch as ovulation problemscertain hormonal conditionsadrenal/pituitary insufficiencythyroid diseasesyndrome of inappropriate antidiuretic hormone-SIADHa certain nervous system problemautonomic neuropathy
Glyburide appears to lower blood glucose acutely by stimulating the release of insulin from the pancreasan effect dependent upon functioning beta cells in the pancreatic isletsThe mechanism by which glyburide lowers blood glucose during long-term administration has not been clearly establishedWith chronic administration in patients with type 2 diabetesthe blood glucose-lowering effect persists despite a gradual decline in the insulin secretory response to the drugExtrapancreatic effects may be involved in the mechanism of action of oral sulfonylurea hypoglycemic drugs.
Discover the best and worst meals for diabetes-savvy diningSee how to avoid carbs and control your blood sugar with healthier.
Stop taking this medication and get medical help right away if you have any symptoms of lactic acidosissuch as unusual tirednessdizzinesssevere drowsinesschillsblue/cold skinmuscle painfast/difficult breathingslow/irregular heartbeator stomach pain with nausea/vomiting/diarrhea.
There are no adequate studies in pregnant womenMost experts agree that insulin is the best treatment for pregnant women with diabetesMetformin is excreted into breast milk and can therefore be transferred to the nursing infantNursing mothers should not use metformin.
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