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Pediatric UseSafety and effectiveness in pediatric patients have not been established.

The side effects of Mestinonpyridostigmineare most commonly related to overdosage and generally are of two varietiesmuscarinic and nicotinicAmong those in the former group are nauseavomitingdiarrheaabdominal crampsincreased peristalsisincreased salivationincreased bronchial secretionsmiosis and diaphoresisNicotinic side effects are comprised chiefly of muscle crampsfasciculation and weaknessMuscarinic side effects can usually be counteracted by atropinebut for reasons shown in the preceding section the expedient is not without dangerAs with any compound containing the bromide radicala skin rash may be seen in an occasional patientSuch reactions usually subside promptly upon discontinuance of the medication.

The safety of Mestinon during pregnancy or lactation in humans has not been establishedThereforeuse of Mestinon in women who may become pregnant requires weighing the drug’s potential benefits against its possible hazards to mother and child.

Safety information for its use in pregnant or breastfeeding women is inadequateThe benefits and risks of the drug should be carefully considered before it is used among these women.

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as is true of all cholinergic drugs, overdosage of mestinon pyridostigmine may result in cholinergic crisis, a state characterized by increasing muscle weakness which, through involvement of the muscles of respiration, may lead to death.

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