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Tell your doctor if you are pregnant or plan to become pregnantYou should not become pregnant while using tacrolimusTacrolimus may harm an unborn babyMen and women using this medication should ask about reliable forms of birth control before and while using this medicationIf you or your partner become pregnanttalk to your doctor right away about the risks and benefits of this medicationDo not stop taking this medication unless directed by your doctor.
ISMP Canada reviewed 33 medication incidents involving these drugs that have been reported internationallyIn most of these incidentsthe mix-up between Prograf and Advagraf occurred during prescribing and/or dispensingThe following common themes were identified from these error reports:
Avoid being near people who are sick or have infectionsTell your doctor at once if you develop signs of infection.
Grapefruit and grapefruit juice may interact with tacrolimus and lead to unwanted side effectsAvoid the use of grapefruit products while taking Prograf.
Dosing should be titrated based on clinical assessments of rejection and tolerabilityLower Prograf dosages than the recommended initial dosage may be sufficient as maintenance therapyAdjunct therapy with adrenal corticosteroids is recommended early post-transplant.
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