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Neonates exposed to Celexa and other SSRIs or serotonin and norepinephrine reuptake inhibitorsSNRIslate in the third trimesterhave developed complications requiring prolonged hospitalizationrespiratory supportand tube feedingSuch complications can arise immediately upon deliveryReported clinical findings have included respiratory distresscyanosisapneaseizurestemperature instabilityfeeding difficultyvomitinghypoglycemiahypotoniahypertoniahyperreflexiatremorjitterinessirritabilityand constant cryingThese features are consistent with either a direct toxic effect of SSRIs and SNRIs orpossiblya drug discontinuation syndromeIt should be noted thatin some casesthe clinical picture is consistent with serotonin syndromesee WARNINGSSerotonin Syndrome

The stated frequencies of adverse events represent the proportion of individuals who experiencedat least oncea treatment-emergent adverse event of the type listedAn event was considered treatmentemergent if it occurred for the first time or worsened while receiving therapy following baseline evaluation.

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