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Increased side effects from other drugsTaking methotrexate with certain medications raises your risk of side effects from those drugsExamples of these drugs include:
In rare instancesthis drug may also cause liver problems when it is used for long periods of timeIf you are using methotrexate long terma liver biopsy is usually recommended.
Methotrexate must not be used during pregnancyIt may harm an unborn babyIt is important to prevent pregnancy during and after treatment with methotrexateThereforemales and females must use reliable forms of birth controlsuch as condomsbirth control pillsduring treatmentMales should continue to use birth control for at least 3 months after the end of treatmentFemales should continue to use birth control for at least 1 menstrual cycle after the end of treatmentIf you become pregnant or think you may be pregnanttell your doctor right away.
This medicine can pass into body fluidsurinefecesvomitCaregivers should wear rubber gloves while cleaning up a patient’s body fluidshandling contaminated trash or laundry or changing diapersWash hands before and after removing glovesWash soiled clothing and linens separately from other laundry.
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use caution if high-dose methotrexate is administered to patients receiving proton pump inhibitor ppi therapy.