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Advise females of reproductive potential of the risk to a fetusto use effective contraception during treatmentand to inform their healthcare provider of a known or suspected pregnancysee CONTRAINDICATIONS and Use in Specific Populations

It is recommended that liver enzyme tests be performed before the initiation of CRESTORand if signs or symptoms of liver injury occur.

In patients with chronic alcohol liver diseaseplasma concentrations of rosuvastatin were modestly increased.

Public Citizen demanded the FDA recall the drug before any further incidents of rhabdomyolysiskidney failure or kidney damage could occur.

Caution should be exercised when anticoagulants are given in conjunction with CRESTOR because of its potentiation of the effect of coumarin-type anticoagulants in prolonging the prothrombin time/INRIn patients taking coumarin anticoagulants and CRESTOR concomitantlyINR should be determined before starting CRESTOR and frequently enough during early therapy to ensure that no significant alteration of INR occurssee DRUG INTERACTIONS

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