Imuran is used for the treatment of rheumatoid arthritis heavy cases.
Information about Imuran.
Imuran therapy should not be initiated in patients who may be pregnantor who are likely to become pregnant without careful assessment of risk versus benefitsee Special Warnings and Precautions for UsePregnancy and Lactation
Benefit versus risk must be weighed carefully before use of IMURAN in patients of reproductive potentialThere are no adequate and well-controlled studies in pregnant womenIf this drug is used during pregnancy or if the patient becomes pregnant while taking this drugthe patient should be apprised of the potential hazard to the fetusWomen of childbearing age should be advised to avoid becoming pregnant.
Renal transplant patients are known to have an increased risk of malignancypredominantly skin cancer and reticulum cell or lymphomatous tumorsThe risk of post-transplant lymphomas may be increased in patients who receive aggressive treatment with immunosuppressive drugsincluding IMURANThereforeimmunosuppressive drug therapy should be maintained at the lowest effective levels.
Macrophage activation syndromeMASis a knownlife-threatening disorder that may develop in patients with autoimmune conditionsin particular with inflammatory bowel diseaseIBDand there could potentially be an increased susceptibility for developing the condition with the use of azathioprineIf MAS occursor is suspectedevaluation and treatment should be started as early as possibleand treatment with azathioprine should be discontinuedPhysicians should be attentive to symptoms of infection such as EBV and cytomegalovirusCMVas these are known triggers for MAS.
Limited evidence suggests that Imuran is not beneficial to patients with hypoxanthine-guanine-phosphoribosyltransferase deficiencyLesch-Nyhan syndromeThereforegiven the abnormal metabolism in these patientsit is not prudent to recommend that these patients should receive Imuran.
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tell your doctor if you experience unlikely but serious side effects of imuran including .