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The value of monitoring plasma concentrations of lamotrigine in patients treated with lamictal xr has not been established.

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Lamotrigine is used either alone or in combination with other medications to treat epileptic seizures in adults and childrenLamotrigine is also used to delay mood episodes in adults with bipolar disordermanic depression

RECOMMENDATIONHealthcare professionals should be aware that prompt recognition and early treatment is important for improving HLH outcomes and decreasing mortalityDiagnosis is often complicated because early signs and symptoms such as fever and rash are not specificHLH may also be confused with other serious immune-related adverse reactions such as Drug Reaction with Eosinophilia and Systemic SymptomsDRESS

Lamotrigine binds to melanin-containing tissuese.gin the eye and pigmented skinIt has been found in the uveal tract up to 52 weeks after a single dose in rodents.

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