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Additionally, the use of dehydroemetine or chloroquine could be considered in severe or refractory cases.

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Maculopathy and macular degeneration have been reported and may be irreversiblesee WARNINGSirreversible retinal damage in patients receiving long-term or high-dosage 4-aminoquinoline therapyvisual disturbancesblurring of vision and difficulty of focusing or accommodationnyctalopiascotomatous vision with field defects of paracentralpericentral ring typesand typically temporal scotomase.gdifficulty in reading with words tending to disappearseeing half an objectmisty visionand fog before the eyesReversible corneal opacities have also been reported.

These are not all of the side effects that may occurIf you have questions about side effectscall your doctorCall your doctor for medical advice about side effects.

Pediatric DoseThe weekly suppressive dosage is 5 mg calculated as baseper kg of body weightbut should not exceed the adult dose regardless of weight.

Patients infected with a resistant strain of plasmodia as shown by the fact that normally adequate doses have failed to prevent or cure clinical malaria or parasitemia should be treated with another form of antimalarial therapy.

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