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In patients with epilepsythe clinical state and electroencephalogram should be monitored at regular intervalssince deterioration in seizure control and EEG have been reported occasionally in patients taking Lioresal.
Treatment Suggestions for OverdoseThere is no specific antidote for treating overdoses of LIORESAL INTRATHECALbaclofen injectionhoweverthe following steps should ordinarily be undertaken:
Screening Patients should be infection-free prior to the screening trial with LIORESAL INTRATHECALbaclofen injectionbecause the presence of a systemic infection may interfere with an assessment of the patient’s response to bolus LIORESAL INTRATHECAL.
All patients receiving intrathecal baclofen therapy are potentially at risk for withdrawalEarly symptoms of baclofen withdrawal may include return of baseline spasticitypruritushypotensionand paresthesiasPriapism may develop or recur if treatment with intrathecal baclofen is interruptedSome clinical characteristics of the advanced intrathecal baclofen withdrawal syndrome may resemble autonomic dysreflexiainfectionsepsismalignant hyperthermianeuroleptic-malignant syndromeor other conditions associated with a hypermetabolic state or widespread rhabdomyolysis.
Additional considerations pertaining to dosage adjustmentIt may be important to titrate the dose to maintain some degree of muscle tone and allow occasional spasms to1help support circulatory function2possibly prevent the formation of deep vein thrombosis3optimize activities of daily living and ease of care.
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lioresal intrathecal when introduced directly into the intrathecal space permits effective csf concentrations to be achieved with resultant plasma concentrations 100 times less than those occurring with oral administration.