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Limited data are available with regard to overdose in humansThe most likely manifestation of overdose would be hypotension and tachycardiaBradycardia could occur from parasympatheticvagalstimulation.
The use of losartan is not recommended during the first trimester of pregnancysee section 4.4The use of losartan is contraindicated during the 2 nd and 3 rd trimester of pregnancysee section 4.3 and 4.4
In elderly hypertensive patients the plasma concentrations of losartan and its active metabolite do not differ essentially from those found in young hypertensive patients.
Reversible increases in serum lithium concentrations and toxicity have been reported during concomitant administration of lithium with ACE inhibitorsVery rare cases have also been reported with angiotensin II receptor antagonistsCo-administration of lithium and losartan should be undertaken with cautionIf this combination proves essentialserum lithium level monitoring is recommended during concomitant use.
Reduction in the risk of stroke in hypertensive patients with left ventricular hypertrophy documented by ECG.
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