Florinef distinct types of toxic florinef are seen at median lethal doses given intraperitoneally.
Information about Florinef.
Dosage depends on the severity of the disease and the response of the patientPatients should be continually monitored for signs that indicate dosage adjustment is necessarysuch as remissions or exacerbations of the disease and stresssurgeryinfectiontraumasee WARNINGS and PRECAUTIONSGeneral
When administered concurrentlythe following drugs may interact with adrenal corticosteroids.
Development of hypertensionedemahypokalemiaexcessive increase in weightand increase in heart size are signs of overdosage of fludrocortisone acetateWhen these are notedadministration of the drug should be discontinuedafter which the symptoms will usually subside within several dayssubsequent treatment with fludrocortisone acetate should be with a reduced doseMuscular weakness may develop due to excessive potassium loss and can be treated by administering a potassium supplementRegular monitoring of blood pressure and serum electrolytes can help to prevent overdosagesee WARNINGS
To avoid drug-induced adrenal insufficiencysupportive dosage may be required in times of stresssuch as traumasurgeryor severe illnessboth during treatment with fludrocortisone acetate and for a year afterwards.
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