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NEXIUM is contraindicated in patients with known hypersensitivity to substituted benzimidazoles or to any component of the formulationHypersensitivity reactions may include anaphylaxisanaphylactic shockangioedemabronchospasmacute interstitial nephritisand urticariasee ADVERSE REACTIONS

Serum chromogranin ACgAlevels increase secondary to drug-induced decreases in gastric acidityThe increased CgA level may cause false positive results in diagnostic investigations for neuroendocrine tumorsHealthcare providers should temporarily stop esomeprazole treatment at least 14 days before assessing CgA levels and consider repeating the test if initial CgA levels are highIf serial tests are performede.gfor monitoringthe same commercial laboratory should be usedfor testingas reference ranges between tests may varysee CLINICAL PHARMACOLOGY

Avoid administration of PPIs for longer than medically indicatedIf signs or symptoms consistent with CLE or SLE are noted in patients receiving NEXIUMdiscontinue the drug and refer the patient to the appropriate specialist for evaluationMost patients improve with discontinuation of the PPI alone in 4 to 12 weeks.

Taking esomeprazole long-term may cause you to develop stomach growths called fundic gland polypsTalk with your doctor about this risk.

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in nexium and prilosec lawsuits, a growing number of plaintiffs claim that drug makers withheld necessary warnings about severe side effects, and that they would not have used a ppi had they been properly warned of risks.

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