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Plasma concentrations of orlistat and its metabolites M1 and M3 were similar to those found in adults at the same dose levelDaily fecal fat excretions were 27and 7of dietary intake in XENICAL and placebo treatment groupsrespectively.
Plasma concentrations of orlistat and its metabolites M1 and M3 were similar to those found in adults at the same dose levelDaily fecal fat excretions were 27and 7of dietary intake in XENICAL and placebo treatment groupsrespectively.
There have been rare postmarketing reports of severe liver injury with hepatocellular necrosis or acute hepatic failure in patients treated with XENICALwith some of these cases resulting in liver transplant or deathPatients should be instructed to report any symptoms of hepatic dysfunctionanorexiapruritusjaundicedark urinelight-colored stoolsor right upper quadrant painwhile taking XENICALWhen these symptoms occurXENICAL and other suspect medications should be discontinued immediately and liver function tests and ALT and AST levels obtained.
No pharmacokinetic study was conducted for specific populations such as geriatricdifferent racesand patients with renal and hepatic impairment.
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