Feldene interacts with the following drugs a blood thinner such as warfarin; lithium; methotrexate;.
Information about Methotrexate.
In rare instancesthis drug may also cause liver problems when it is used for long periods of timeIf you are using methotrexate long terma liver biopsy is usually recommended.
Avoid exposure to sunlight or artificial UV rayssunlamps or tanning bedsespecially if you are being treated for psoriasisMethotrexate can make your skin more sensitive to sunlight and your psoriasis may worsen.
Do not receive alivevaccine while using methotrexateor you could develop a serious infectionLive vaccines include measlesmumpsrubellaMMRpoliorotavirustyphoidyellow fevervaricellachickenpoxand zostershingles
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concurrent use of pemetrexed and methotrexate is unlikely, however, the combination should be avoided.