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Elevated systolic or diastolic pressure causes increased cardiovascular riskand the absolute risk increase per mmHg is greater at higher blood pressuresso that even modest reductions of severe hypertension can provide substantial benefitRelative risk reduction from blood pressure reduction is similar across populations with varying absolute riskso the absolute benefit is greater in patients who are at higher risk independent of their hypertensionfor examplepatients with diabetes or hyperlipidemiaand such patients would be expected to benefit from more aggressive treatment to a lower blood pressure goal.

This drug may make you dizzy or drowsyAlcohol or marijuana can make you more dizzy or drowsyDo not driveuse machineryor do anything that needs alertness until you can do it safelyLimit alcoholic beveragesTalk to your doctor if you are using marijuanaSee also How to Use section.

LiverhepaticimpairmentUse with caution in mild-to-moderate hepatic dysfunctiondo not use in severe impairment.

This medication contains doxazosinDo not take CarduraCardura XLor Doxadura if you are allergic to doxazosin or any ingredients contained in this drugKeep out of reach of childrenIn case of overdoseget medical help or contact a Poison Control Center immediately.

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doxazosin mesylate inhibits the binding of norepinephrine to the -1 receptors on the membrane of vascular smooth muscle cells.

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