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EzetimibeZetiais a newly Food and Drug Administration(FDAapproved medication that selectively inhibits the intestinal absorption of cholesterol and related phytosterolsIt is approved for primary hypercholesterolemiaheterozygous familial and nonfamilial hypercholesterolemiaas monotherapy or in combination with 3-hydroxy-3-methylglutaryl coenzyme AHMG-CoAreductase inhibitorsstatinsIt is also indicated in combination with atorvastatin or simvastatin for homozygous familial hypercholesterolemia and as an adjunct to diet for homozygous sitosterolemia1

It is not known whether ezetimibe is excreted into human breast milkIn rat studiesexposure to total ezetimibe in nursing pups was up to half of that observed in maternal plasmaBecause many drugs are excreted in human milkcaution should be exercised when ZETIA is administered to a nursing womanZETIA should not be used in nursing mothers unless the potential benefit justifies the potential risk to the infant.

From this studyit may be concluded that addition of ezetimibe has incremental effects on LDL cholesterol reductionIn patients with a high risk of hepatic insufficiencythe addition of ezetimibe to the lowest dose of lovastatin may be helpful in preventing adverse effects of high-dose lovastatin while gaining the full benefits of high-dose lovastatinAlsothe combination of ezetimibe and lovastatin has no greater adverse effects than lovastatin monotherapy7

This drug may increase the risk of liver damagewhen taken with astatinor muscle damage when taken with a fibrate orstatinTell your doctor right away if you experience any of the following symptomssigns of liver problemssuch as severe stomach/abdominal painpersistent nausea/vomitingyellowing eyes/skindark urinemuscle pain/tenderness/weaknessespecially with fever or unusual tiredness

If you also take cholestyraminecolestipolor colesevelamWait at least 4 hours after taking any of these medicines before you take ezetimibeYou may also take ezetimibe 2 hours before taking any of these other medicines.

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