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Both are taken as part of a wider cessation programme including motivational support.

Nicotineadministered transdermally by patchesdid not affect the pharmacokinetics of bupropion and its metabolites.

It is recommended that you do not try to quit smoking until you have been taking bupropion for 1 week so that the drug can reach a high enough level in your bloodSet a date for quittingand stop smoking sometime in the second week of taking the drug.

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Smoking is associated with an increase in CYP1A2 activityAfter cessation of smokingreduced clearance of medicinal products metabolised by this enzymewith subsequent increases in plasma levelsmay occurThis may be particularly important for those medicinal products primarily metabolised by CYP1A2 with narrow therapeutic windowse.gtheophyllinetacrine and clozapineThe clinical consequences of smoking cessation on other medicinal products that are partially metabolised by CYP1A2e.gimipramineolanzapineclomipramineand fluvoxamineare unknownIn additionlimited data indicate that the metabolism of flecainide or pentazocine may also be induced by smoking.

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persons prescribed with zyban or wellbutrin should have their blood pressure tested before starting treatment and routinely monitored thereafter.

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