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Exercise caution when patients with mild to moderate hepatic dysfunction due to liver metastases are treated with XELODAThe effect of severe hepatic dysfunction on XELODA is not knownsee WARNINGS AND PRECAUTIONS and CLINICAL PHARMACOLOGY

Table 5 Percent Incidence of Grade 3/4 Laboratory Abnormalities Reported in1of Patients Receiving XELODA Monotherapy for Adjuvant Treatment of Colon CancerSafety Population)

You have blood tests before starting treatment and during your treatmentThey check your levels of blood cells and other substances in the bloodThey also check how well your liver and kidneys are working.

Because clinical trials are conducted under widely varying conditionsadverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in practice.

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