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The compound is cumulative in action and will require several weeks to exert its beneficial therapeutic effectswhereas minor side effects may occur relatively earlySeveral months of therapy may be required before maximum effects can be obtainedIf objective improvementsuch as reduced joint swellingincreased mobilitydoes not occur within six monthsthe drug should be discontinuedSafe use of the drug in the treatment of juvenile rheumatoid arthritis has not been established.

DVisual field defectsPericentral or paracentral scotomacentral scotoma with decreased visual acuityrarely field constrictionabnormal color vision.

For lupus or rheumatoid arthritistake this medication by mouthusually once or twice daily or as directedYour doctor may gradually increase your doseOnce you have been taking the medication for a while and your condition has improvedyour doctor may instruct you to lower your dose until you find the dose that works best with the fewest side effects.

An interaction between two medications does not always mean that you must stop taking one of themSpeak to your doctor about how any drug interactions are being managed or should be managed.

The incidence of retinopathy has been reported to be higher when this maintenance dose is exceeded.

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