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The adverse reactions listed in the table are based on post-marketing spontaneousreporting rateclinical trials and class-effects.

Have regular physical exams and self-examine your breasts for lumps on a monthly basis while using Premarin.

For the treatment of postmenopausal symptomsHRT should only be initiated for symptoms that adversely affect quality of lifeIn all casesa careful appraisal of the risks and benefits should be undertaken at least annually and HRT should only be continued as long as the benefit outweighs the risk.

Endogenous estrogens are largely responsible for the development and maintenance of the female reproductive system and secondary sexual characteristicsAlthough circulating estrogens exist in a dynamic equilibrium of metabolic interconversionsestradiol is the principal intracellular human estrogen and is substantially more potent than its metabolitesestrone and estriolat the receptor level.

PREMARIN Vaginal Cream is not indicated in childrenClinical studies have not been conducted in the pediatric population.

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