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Premarin conjugated estrogens tablets for oral administration contains a mixture of conjugated estrogens obtained exclusively from natural sources, occurring as the sodium salts of water-soluble estrogen sulfates blended to represent the average composition of material derived from pregnant mares urine.

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The adverse reactions listed in the table are based on post-marketing spontaneousreporting rateclinical trials and class-effects.

In women with no personal history of VTE but with a first degree relative with a history of thrombosis at young agescreening may be offered after careful counselling regarding its limitationsonly a proportion of thrombophilic defects are identified by screeningIf a thrombophilic defect is identified which segregates with thrombosis in family members or if the defect isseveree.gantithrombinprotein Sor protein C deficiencies or a combination of defectsHRT is contraindicated.

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