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Symptoms of overdosage may include drowsinessdisorientation and extrapyramidal reactionsAnticholinergic or antiparkinson drugs or antihistamines with anticholinergic properties may be helpful in controlling the extrapyramidal reactionsSymptoms are self-limiting and usually disappear within 24 hours.

In pediatric patientsthe pharmacodynamics of metoclopramide following oral and intravenous administration are highly variable and a concentration-effect relationship has not been established.

Reglan Injection is known to be substantially excreted by the kidneyand the risk of toxic reactions to this drug may be greater in patients with impaired renal functionsee DOSAGE AND ADMINISTRATIONUse in Patients With Renal or Hepatic Impairment

Intravenous administration of Reglan Injection diluted in a parenteral solution should be made slowly over a period of not less than 15 minutes.

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