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In one uncontrolled study, patients with low cardiac indices and elevated systemic vascular resistance following intravenous trandate experienced significant declines in cardiac output with little change in systemic vascular resistance.

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When gradually stopping this medicationit is recommended that you temporarily limit physical activity to decrease strain on the heartSeek immediate medical attention if you develop chest pain/tightness/pressurechest pain spreading to the jaw/neck/armunusual sweatingtrouble breathingor fast/irregular heartbeat.

Do not stop taking labetalol without first talking to your doctorStopping suddenly may make your condition worse.

Labetalol may also be used for purposes not listed in this medication guide.

Due to the alpha 1receptor blocking activity of labetalol HClblood pressure is lowered more in the standing than in the supine positionand symptoms of postural hypotension2including rare instances of syncopecan occurFollowing oral administrationwhen postural hypotension has occurredit has been transient and is uncommon when the recommended starting dose and titration increments are closely followedsee DOSAGE AND ADMINISTRATIONSymptomatic postural hypotension is most likely to occur 2 to 4 hours after a doseespecially following the use of large initial doses or upon large changes in dose.

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