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The safe use of triamterene and hydrochlorothiazide in pregnancy has not been established since there are no adequate and well-controlled studies with triamterene and hydrochlorothiazide in pregnant women.

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Hydrochlorothiazidea sulfonamidecan cause an idiosyncratic reactionresulting in acute transient myopia and acute angle-closure glaucomaSymptoms include acute onset of decreased visual acuity or ocular pain and typically occur within hours to weeks of drug initiationUntreated acute angle-closure glaucoma can lead to permanent vision lossThe primary treatment is to discontinue hydrochlorothiazide as rapidly as possiblePrompt medical or surgical treatments may need to be considered if the intraocular pressure remains uncontrolledRisk factors for developing acute angle-closure glaucoma may include a history of sulfonamide or penicillin allergy.

Studies of the effects of MAXZIDEthe triamterene/hydrochlorothiazide combinationor of triamterene alone on animal reproductive function have not been conducted.

No specific data are available regarding MAXZIDEtriamterene and hydrochlorothiazideoverdosage in humans and no specific antidote is available.

Studies of the mutagenic potential of MAXZIDEthe triamterene/hydrochlorothiazide combinationhave not been performed.

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chronic or overuse of laxatives may reduce serum potassium levels by promoting excessive potassium loss from the intestinal tract; laxatives may interfere with the potassium-retaining effects of triamterene.

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