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Orlistat can make it harder for your body to absorb certain vitaminsand you may need to take a vitamin and mineral supplement while you are taking this medicineFollow your doctor’s instructions about the type of supplement to useTake the supplement at bedtimeor at least 2 hours before or after you take orlistat.

The dose-response relationship for orlistat in human volunteers is shown in Figure 1The effect is the percentage of ingested fat excretedreferred to as fecal fat excretion percentageBoth individual dataopen circlesand the curve predicted for the population with the maximum-effect modelcontinuous lineare shown in Figure 1.

Orlistat blocks your body’s absorption of some fat-soluble vitamins and beta caroteneThereforewhen you use orlistat you should take a daily multivitamin that contains vitamins ADEKand beta-caroteneRead the label to find a multivitamin product that contains these vitaminsTake the multivitamin once a day2 hours before or 2 hours after taking orlistator take the multivitamin at bedtimeAsk your doctor or pharmacist any questions you might have about taking a multivitamin while you are taking orlistat.

Store at room temperature away from moistureheatand lightKeep the bottle tightly closedThrow away any unused orlistat after the expiration date on the medicine label has passed.

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in a large randomized controlled trial, orlistat was found to reduce the incidence of diabetes by nearly 40 in obese people with evidence of impaired glucose metabolism.

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