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Table 1 interactions with oral contraceptives6, 7 drug class examples effect examples that do not affect ocs anti-epileptics carbamazepine induce liver enzymes resulting in ethosuximide oxcarbazepine a reduction in ethinyloestradiol gabapentin phenytoin and progestogen concentrations lamotrigine antibiotics phenobarbital levetiracetam primidone valproate topiramate vigabatrin rifampicin induce liver enzymes resulting in rifabutin a reduction in ethinyloestradiol no alternatives and progestogen concentrations, breakthrough bleeding all other antibiotics potential reduction in narrow- and broad- ethinyloestradiol concentration spectrum due to effect on gut flora bpj issue 12 23 table 2 components of combined oral contraceptives coc 3, 5, 11 oestrogen level progestogen ethinyloestradiol micrograms micrograms 20 micrograms levonorgestrel 100 brand names loette microgynon 20 ed desogestrel 150 mercilon 21 mercilon 28 30 micrograms gestodene 75 femodene 28 minulet 28 levonorgestrel 150 levlen ed microgynon 30 microgynon 30 ed monofeme nordette desogestrel 150 marvelon 21 marvelon 28 35 micrograms drospirenone 3000 yasmin cyproterone 2000 estelle 35 ed diane-35 ed norethisterone 500 norimin norethisterone 1000 brevinor 1 21 brevinor 1 28 50 micrograms levonorgestrel 125 microgynon 50 ed phasic levonorgestrel trifeme 28 30 40 30 50 75 125 triphasil 28 triquilar ed mestranol 50 micrograms norethisterone 1000 fully funded mestranol is converted in the liver to ethinyloestradiol; 50 micrograms of mestranol is pharmacologically equivalent to 35 micrograms of ethinyloestradiol.

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COCs have been shown to increase both the relative and attributable risks of cerebrovascular eventsthrombotic and hemorrhagic strokesalthoughin generalthe risk is greatest among older35 years of agehypertensive women who also smokeCOCs also increase the risk for stroke in women with other underlying risk factors.

These metabolites were shown not to be pharmacologically activeDrospirenone is also subject to oxidative metabolism catalyzed by CYP3A4.

The hormones in Yasmin can pass into breast milk and may harm a nursing babyThis medicine may also slow breast milk productionDo not use if you are breast feeding.

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